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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620597
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plaur
Name: plasminogen activator, urokinase receptor
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plauraffects expressionEXP 6480464CTDAspirin affects the expression of PLAUR mRNAPMID:12800193
Plaurincreases expressionISOPLAUR (Homo sapiens)6480464CTDAspirin results in increased expression of PLAUR mRNA; Aspirin results in increased expression of PLAUR proteinPMID:16893520
Plaurmultiple interactionsISOPLAUR (Homo sapiens)6480464CTDAspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]; Aspirin promotes the reaction [H4C16 protein modified form binds to PLAUR promoter]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter]PMID:16893520
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