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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaaffects expressionEXP 6480464CTDAspirin affects the expression of VEGFA mRNAPMID:12800193
Vegfadecreases expressionEXP 6480464CTDAspirin results in decreased expression of VEGFA mRNAPMID:12231391
Vegfamultiple interactionsEXP 6480464CTDAmpicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]]; Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]PMID:21893697 PMID:29031619
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDAspirin results in decreased expression of VEGFAPMID:15345513
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDnitroaspirin inhibits the reaction [Aspirin results in decreased expression of VEGFA]PMID:15345513
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