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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3825
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbxa2r
Name: thromboxane A2 receptor
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbxa2raffects response to substanceISOTBXA2R (Homo sapiens)6480464CTDTBXA2R gene SNP affects the susceptibility to Aspirin; TBXA2R polymorphism affects the susceptibility to AspirinPMID:20485159 PMID:21070398
Tbxa2rdecreases response to substanceISOTBXA2R (Homo sapiens)6480464CTDTBXA2R SNP results in decreased susceptibility to AspirinPMID:17245331
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