Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2199
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Bcl2
Name:	BCL2, apoptosis regulator

Acc ID:	CHEBI:15365
Term:	acetylsalicylic acid
Definition:	A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID:	MESH:D001241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Bcl2	multiple interactions	EXP		6480464	CTD	Aspirin inhibits the reaction [Azoxymethane results in increased expression of BCL2 mRNA]	PMID:20043115
Bcl2	decreases expression	ISO	Bcl2 (Mus musculus)	6480464	CTD	Aspirin results in decreased expression of BCL2 protein	PMID:20886344
Bcl2	decreases expression	ISO	BCL2 (Homo sapiens)	6480464	CTD	Aspirin results in decreased expression of BCL2 mRNA; Aspirin results in decreased expression of BCL2 protein	PMID:12490308 PMID:14636445 PMID:15976387 PMID:16199534 PMID:18564172 PMID:19424877 PMID:19595669 PMID:19966835 PMID:20457246
Bcl2	increases expression	ISO	BCL2 (Homo sapiens)	6480464	CTD	Aspirin results in increased expression of BCL2 mRNA; Aspirin results in increased expression of BCL2 protein	PMID:17342322 PMID:18636671
Bcl2	multiple interactions	ISO	Bcl2 (Mus musculus)	6480464	CTD	Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]	PMID:25449198 PMID:37179038
Bcl2	multiple interactions	ISO	BCL2 (Homo sapiens)	6480464	CTD	Aspirin inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]	PMID:16199534 PMID:23799623

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