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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDAspirin results in increased expression of BAX proteinPMID:30885738
Baxmultiple interactionsEXP 6480464CTDBee Venoms inhibits the reaction [Aspirin results in increased expression of BAX protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]PMID:30885738
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDAspirin results in decreased expression of BAX mRNA; Aspirin results in decreased expression of BAX proteinPMID:18636671 PMID:20457246
Baxincreases expressionISOBax (Mus musculus)6480464CTDAspirin results in increased expression of BAX proteinPMID:16880202
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDAspirin results in increased expression of BAX proteinPMID:11532860 PMID:15986848 PMID:19212664
Baxincreases localizationISOBAX (Homo sapiens)6480464CTDAspirin results in increased localization of BAX proteinPMID:11228543 PMID:15976387
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDAspirin inhibits the reaction [Cisplatin results in increased expression of BAX protein]PMID:37179038
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein]PMID:15976387 PMID:15986848
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