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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731069
Species: Mus musculus
RGD Object: Gene
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm1affects bindingISOCHRM1 (Homo sapiens)6480464CTDAcetylcholine binds to CHRM1 protein; CHRM1 protein binds to AcetylcholinePMID:10069518 PMID:10860942 PMID:9224827 PMID:9495826
Chrm1increases activityISOChrm1 (Rattus norvegicus)6480464CTDAcetylcholine results in increased activity of CHRM1 proteinPMID:14534362
Chrm1increases activityISOCHRM1 (Homo sapiens)6480464CTDAcetylcholine results in increased activity of CHRM1 proteinPMID:11527950 PMID:31830555
Chrm1multiple interactionsISOChrm1 (Rattus norvegicus)6480464CTDPregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]PMID:14534362 PMID:15900516
Chrm1multiple interactionsISOCHRM1 (Homo sapiens)6480464CTD[Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Acetylcholine binds to and results in increased activity of CHRM1 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Endocannabinoids promotes the reaction [Acetylcholine binds to and results in increased activity of CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]PMID:10069518 PMID:10101037 PMID:10860942 PMID:11527950 PMID:30102254 PMID:9224827 PMID:9495826
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