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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10997
Species: Mus musculus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3affects response to substanceEXP 6480464CTDNOS3 protein affects the susceptibility to AcetylcholinePMID:17403420
Nos3increases response to substanceEXP 6480464CTDNOS3 protein results in increased susceptibility to AcetylcholinePMID:15381055
Nos3increases phosphorylationISONos3 (Rattus norvegicus)6480464CTDAcetylcholine results in increased phosphorylation of NOS3 proteinPMID:25108154
Nos3multiple interactionsISONos3 (Rattus norvegicus)6480464CTDAICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]; Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]; resveratrol inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]PMID:10954898 PMID:25108154
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