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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10multiple interactionsISOIl10 (Mus musculus)6480464CTD5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of IL10 mRNA; [Dietary Fats co-treated with Choline deficiency] results in increased expression of IL10 protein; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of IL10 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]; PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of IL10 protein]; Resveratrol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]PMID:28973532 PMID:29246445 PMID:30745416
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