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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69473
Species: Homo sapiens
RGD Object: Gene
Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF1multiple interactionsISOSrebf1 (Rattus norvegicus)6480464CTD[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SREBF1 mRNA; geraniol promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SREBF1 mRNA]PMID:26695085
SREBF1multiple interactionsISOSrebf1 (Mus musculus)6480464CTD5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]; 5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]; pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]]PMID:19593819 PMID:27773935 PMID:28973532 PMID:30745416
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