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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552388
Species: Mus musculus
RGD Object: Gene
Symbol: Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acacadecreases expressionEXP 6480464CTDCholine deficiency results in decreased expression of ACACA mRNAPMID:25178843
Acacamultiple interactionsEXP 6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]]; Smoke promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACACA mRNA]PMID:18952117 PMID:27773935 PMID:28973532 PMID:31678261
Acacamultiple interactionsISOAcaca (Rattus norvegicus)6480464CTD[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA; [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACACA mRNAPMID:19566968 PMID:22648174
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