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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348351
Species: Homo sapiens
RGD Object: Gene
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACTA2multiple interactionsISOActa2 (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ACTA2 mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACTA2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ACTA2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of ACTA2 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA]; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 protein]; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA]; CCL2 protein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; fuzheng huayu inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; fuzheng huayu inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; Pioglitazone inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]; Smoke affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACTA2 mRNA]; tianhuang inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; tianhuang inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]PMID:18513333 PMID:18952117 PMID:20697377 PMID:20938992 PMID:22915297 PMID:23439872 PMID:27773935 PMID:27984176 PMID:28100771 PMID:28133511 PMID:29883724 PMID:31678261 PMID:38042390
ACTA2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTD[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]PMID:26695085
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