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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10685
Species: Mus musculus
RGD Object: Gene
Symbol: Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin1multiple interactionsEXP 6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN1 genePMID:20938992
Grin1multiple interactionsISOGrin1 (Rattus norvegicus)6480464CTDCholine analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 mRNA]; Choline analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 protein]PMID:20381573
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