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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDAcetaldehyde results in decreased expression of BCL2 mRNA; Acetaldehyde results in decreased expression of BCL2 proteinPMID:16814256 PMID:35158046
BCL2multiple interactionsEXP 6480464CTDADIPOQ protein inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]; Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]PMID:16814256 PMID:35158046
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