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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of AcetaldehydePMID:10826103
CYP2E1multiple interactionsEXP 6480464CTD[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of AcetaldehydePMID:18845238
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde; phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]PMID:7562599
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