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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307148
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col4a1
Name: collagen type IV alpha 1 chain
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col4a1decreases expressionISOCOL4A1 (Homo sapiens)6480464CTDAcetaldehyde results in decreased expression of COL4A1 mRNA; Acetaldehyde results in decreased expression of COL4A1 proteinPMID:8135774
Col4a1multiple interactionsISOCOL4A1 (Homo sapiens)6480464CTDTGFB1 protein inhibits the reaction [Acetaldehyde results in decreased expression of COL4A1 protein]PMID:8135774
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