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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:15335
Term: 5,7-dihydroxy-4'-methoxyflavone
Definition: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
Chemical ID: MESH:C023717
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1increases expressionEXP 6480464CTDacacetin results in increased expression of CYP1B1 mRNAPMID:31621310
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDacacetin results in decreased activity of CYP1B1 proteinPMID:10781868
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDacacetin results in increased expression of CYP1B1 mRNAPMID:31621310
Cyp1b1increases metabolic processingISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 protein results in increased metabolism of acacetinPMID:21482471
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTDacacetin binds to and results in decreased activity of CYP1B1 proteinPMID:21053930
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