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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:149489
Term: 5,5-dimethyl-1-pyrroline N-oxide
Definition: A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.
Chemical ID: MESH:C017245
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpomultiple interactionsISORGD:13463846480464CTD4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5, 5-dimethyl-1-pyrroline-1-oxide], [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5, 5-dimethyl-1-pyrroline-1-oxide, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 4-dichloroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 4-xylidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 6-xylidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3, 4-dichloroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3, 4-xylidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form, [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form, [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5, 5-dimethyl-1-pyrroline-1-oxide, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 4-dichloroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 4-xylidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2, 6-xylidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3, 4-dichloroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3, 4-xylidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline, [MPO protein co-treated with Hydrogen Peroxide co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide, desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5, 5-dimethyl-1-pyrroline-1-oxide]

PMID:20199096, PMID:28754375
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.