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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:146245
Term: SR 144528
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid with the amino group of (1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-amine. A potent and selective cannabinoid receptor type 2 (CB2 receptor) inverse agonist (Ki = 0.6 nM).
Chemical ID: MESH:C110630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTD[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of ATF4 mRNA]PMID:31054322
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