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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10596
Species: Mus musculus
RGD Object: Gene
Symbol: Fos
Name: FBJ osteosarcoma oncogene
Acc ID: CHEBI:146207
Term: palytoxin
Definition: A polyol marine coelenterate toxin composed of substituted N-3-hydroxypropyl-trans-3-amidoacrylamides and produced by species of Palythoa and Zoanthus soft corals (collectively called zoantharians), either as a defence mechanism or to assist them in capturing prey. An ionophore that forms cation channels through Na+/K+-ATPase, it is a potent vasoconstrictor useful in evaluation of anti-angina agents. It is considered to be one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice.
Chemical ID: MESH:C010272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDpalytoxin results in increased expression of FOS mRNAPMID:19716839
Fosmultiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [palytoxin results in increased expression of FOS mRNA]PMID:19716839
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDpalytoxin results in increased expression of FOS mRNAPMID:19716839
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDMAPK7 mutant form inhibits the reaction [palytoxin results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [palytoxin results in increased expression of FOS mRNA]PMID:19716839
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