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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734300
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2l11
Name: BCL2 like 11
Acc ID: CHEBI:145535
Term: pevonedistat
Definition: A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.
Chemical ID: MESH:C539933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11affects expressionISOBCL2L11 (Homo sapiens)6480464CTDpevonedistat affects the expression of BCL2L11 mRNA; pevonedistat affects the expression of BCL2L11 proteinPMID:24634471
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