GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | increases cleavage | EXP | | 6480464 | CTD | pevonedistat results in increased cleavage of PARP1 protein | PMID:24634471 | PARP1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | pevonedistat results in increased cleavage of and results in increased activity of PARP1 protein; Tretinoin promotes the reaction [pevonedistat results in increased cleavage of and results in increased activity of PARP1 protein] | PMID:22110742 | |
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