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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354508
Species: Homo sapiens
RGD Object: Gene
Symbol: CSF2
Name: colony stimulating factor 2
Acc ID: CHEBI:141969
Term: tipifarnib
Definition: A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer).
Chemical ID: MESH:C402769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CSF2decreases activityEXP 6480464CTDtipifarnib results in decreased activity of CSF2 proteinPMID:22315502
CSF2multiple interactionsEXP 6480464CTDtipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein]; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein]; tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein]PMID:22315502
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