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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12b
Name: interleukin 12B
Acc ID: CHEBI:141319
Term: metam
Definition: A member of the class of dithiocarbamic acids that is dithiocarbamic acid in which a hydrogen attached to the amino group has been replaced by a methyl group. It is used (most widely as the corresponding sodium salt, metam-sodium) as an agricultural pesticide, mainly as a broad spectrum soil fumigant for the control of weeds, nematodes, soil-borne insects and fungi.
Chemical ID: MESH:C008435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12bmultiple interactionsISORGD:7328576480464CTD[Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

PMID:15933225 PMID:16321413 PMID:19339665 PMID:24056979
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