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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732177
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:140621
Term: cisatracurium
Definition: A diester that is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium, a quaternary ammonium ion consisting of pentane-1,5-diol with both hydroxy functions bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups. The active species in the skeletal muscle relaxant cisatracurium besylate.
Chemical ID: MESH:C101584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4decreases expression ISOCXCR4 (Homo sapiens)151893498RGDcisatracurium decreases expression of CXCR4 mRNA and protein in colonic epithelium 
Cxcr4decreases expressionISOCXCR4 (Homo sapiens)6480464CTDcisatracurium results in decreased expression of CXCR4 mRNA; cisatracurium results in decreased expression of CXCR4 proteinPMID:33617803
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTDCXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]PMID:33617803
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