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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1affects response to substanceISOSOD1 (Homo sapiens)6480464CTDSOD1 protein affects the susceptibility to N-Methyl-3,4-methylenedioxyamphetaminePMID:11435997
Sod1decreases activityISOSod1 (Mus musculus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of SOD1 proteinPMID:11435997
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDSOD1 protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of CAT protein]; SOD1 protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of SOD1 protein]PMID:11435997
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