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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a4
Name: solute carrier family 6 member 4
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a4decreases expressionEXP 6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 mRNA; N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 proteinPMID:16054768 PMID:16489401 PMID:25370842
Slc6a4decreases response to substanceEXP 6480464CTDSLC6A4 gene mutant form results in decreased susceptibility to N-Methyl-3,4-methylenedioxyamphetaminePMID:24595820
Slc6a4multiple interactionsEXP 6480464CTD2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 protein]PMID:25370842
Slc6a4affects bindingISOSLC6A4 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine binds to SLC6A4 proteinPMID:16272152
Slc6a4affects expressionISOSLC6A4 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine affects the expression of SLC6A4 proteinPMID:20483717
Slc6a4decreases activityISOSLC6A4 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of SLC6A4 proteinPMID:30776375
Slc6a4decreases expressionISOSLC6A4 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 proteinPMID:18661256
Slc6a4multiple interactionsISOSLC6A4 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine affects the reaction [N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine binds to SLC6A4 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]PMID:20483717 PMID:28506818 PMID:29908239 PMID:30776375
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