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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312771
Species: Homo sapiens
RGD Object: Gene
Symbol: PKNOX1
Name: PBX/knotted 1 homeobox 1
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PKNOX1decreases expressionISOPknox1 (Mus musculus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PKNOX1 mRNAPMID:26251327
PKNOX1increases expressionISOPknox1 (Mus musculus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PKNOX1 mRNAPMID:20188158
PKNOX1increases methylationISOPknox1 (Mus musculus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PKNOX1 promoterPMID:26251327
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