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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10357
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna7increases activityISOCHRNA7 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CHRNA7 proteinPMID:20132834
Chrna7multiple interactionsISOCHRNA7 (Homo sapiens)6480464CTD1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CHRNA7 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]PMID:20132834
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