Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69169
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Pparg
Name:	peroxisome proliferator activated receptor gamma

Acc ID:	CHEBI:139030
Term:	hydroxysafflor yellow A
Definition:	A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Chemical ID:	MESH:C085278

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Pparg	multiple interactions	ISO	Pparg (Rattus norvegicus)	6480464	CTD	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased expression of PPARG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased expression of PPARG protein]	PMID:24192212

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