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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:138502
Term: etazolate
Definition: A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Chemical ID: MESH:D004974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il13decreases expressionISORGD:690086480464CTDEtazolate results in decreased expression of IL13 mRNA

PMID:16083514
Il13decreases secretionISORGD:690086480464CTDEtazolate results in decreased secretion of IL13 protein

PMID:16083514
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.