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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:138308
Term: kahweol
Definition: A diterpenoid with formula C20H26O3, isolated from the beans of Coffea arabica. It exhibits antioxidant, anti-inflammatory, anti-angiogenesis and anti-proliferative properties.
Chemical ID: MESH:C053401
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:104736480464CTD[cafestol co-treated with kahweol] results in increased expression of NQO1 mRNA, [cafestol co-treated with kahweol] results in increased expression of NQO1 protein, NFE2L2 protein promotes the reaction [[cafestol co-treated with kahweol] results in increased expression of NQO1 mRNA]

PMID:18028974
multiple interactionsISORGD:25036480464CTD[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of NQO1 protein]

PMID:17110534
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.