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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735647
Species: Mus musculus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:138236
Term: oridonin
Definition: An organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens.
Chemical ID: MESH:C011959
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTDoridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:30243739
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