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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:138236
Term: oridonin
Definition: An organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens.
Chemical ID: MESH:C011959
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDoridonin results in decreased expression of IFNG proteinPMID:18351433
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDoridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]PMID:31594861
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDoridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]PMID:31594861
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