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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:138236
Term: oridonin
Definition: An organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens.
Chemical ID: MESH:C011959
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDoridonin results in increased cleavage of PARP1 proteinPMID:16019488
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDoridonin analog results in decreased expression of and results in increased cleavage of PARP1 proteinPMID:31594861
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