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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266
Species: Homo sapiens
RGD Object: Gene
Symbol: FAS
Name: Fas cell surface death receptor
Acc ID: CHEBI:137832
Term: Cacalol
Definition: null
Chemical ID: MESH:C497192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASdecreases expressionEXP 6480464CTDcacalol results in decreased expression of FAS mRNA; cacalol results in decreased expression of FAS proteinPMID:20665104
FASmultiple interactionsEXP 6480464CTD[Cyclophosphamide co-treated with cacalol] results in decreased expression of FAS protein; cacalol inhibits the reaction [Hydrogen Peroxide results in increased expression of FAS mRNA]; cacalol inhibits the reaction [SREBF1 protein binds to FAS promoter]; cacalol promotes the reaction [Paclitaxel results in decreased expression of FAS mRNA]; Paclitaxel promotes the reaction [cacalol results in decreased expression of FAS mRNA]PMID:20665104
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