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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732739
Species: Homo sapiens
RGD Object: Gene
Symbol: ARNT
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:1367
Term: 3,3',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.
Chemical ID: MESH:C028451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARNTmultiple interactionsEXP 6480464CTD3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 3,4,3',4'-tetrachlorobiphenyl results in increased activity of [AHR protein binds to ARNT protein]; resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]PMID:11294989 PMID:16972788 PMID:18708364
ARNTmultiple interactionsISOArnt (Rattus norvegicus)6480464CTD3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]; resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]PMID:18708364
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