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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732174
Species: Homo sapiens
RGD Object: Gene
Symbol: BCHE
Name: butyrylcholinesterase
Acc ID: CHEBI:136185
Term: VX nerve agent
Definition: A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.
Chemical ID: MESH:C009680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCHEdecreases activityEXP 6480464CTDVX analog results in decreased activity of BCHE protein; VX metabolite results in decreased activity of BCHE protein; VX results in decreased activity of BCHE proteinPMID:17698511 PMID:18617161 PMID:19428953 PMID:22407886 PMID:27358236 PMID:27693733 PMID:29920286 PMID:31863869 PMID:33517499 PMID:36708975
BCHEmultiple interactionsEXP 6480464CTD[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX; asoxime chloride inhibits the reaction [VX results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]; Oximes analog inhibits the reaction [VX results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]; pyridoxaloxime analog inhibits the reaction [VX results in decreased activity of BCHE protein]PMID:22981459 PMID:27358236 PMID:27693733 PMID:29920286 PMID:31863869
BCHEdecreases activityISOBche (Rattus norvegicus)6480464CTDVX results in decreased activity of BCHE proteinPMID:34653647
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