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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732690
Species: Mus musculus
RGD Object: Gene
Symbol: Defb1
Name: defensin beta 1
Acc ID: CHEBI:135938
Term: lasofoxifene
Definition: A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Chemical ID: MESH:C111332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Defb1multiple interactionsEXP 6480464CTD[Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNAPMID:18367319
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