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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:135697
Term: sarpogrelate
Definition: null
Chemical ID: MESH:C064294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases activityISORGD:7362176480464CTDsarpogrelate metabolite results in decreased activity of CYP2D6 protein sarpogrelate results in decreased activity of CYP2D6 protein

PMID:24167220
Cyp2d4multiple interactionsISORGD:7362176480464CTDsarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]

PMID:24167220
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