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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69098
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNJ11
Name: potassium inwardly rectifying channel subfamily J member 11
Acc ID: CHEBI:134126
Term: picrotoxin
Definition: A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.
Chemical ID: MESH:D010852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNJ11decreases expressionISOKcnj11 (Rattus norvegicus)6480464CTDPicrotoxin results in decreased expression of KCNJ11 mRNA; Picrotoxin results in decreased expression of KCNJ11 proteinPMID:18021373
KCNJ11increases expressionISOKcnj11 (Rattus norvegicus)6480464CTDPicrotoxin results in increased expression of KCNJ11 mRNA; Picrotoxin results in increased expression of KCNJ11 proteinPMID:18021373
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