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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62147
Species: Mus musculus
RGD Object: Gene
Symbol: Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Acc ID: CHEBI:134126
Term: picrotoxin
Definition: A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.
Chemical ID: MESH:D010852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabra1multiple interactionsISOGabra1 (Rattus norvegicus)6480464CTDPicrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]PMID:17054655
Gabra1multiple interactionsISOGABRA1 (Homo sapiens)6480464CTDdelta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]PMID:14637376 PMID:9316872
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