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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348090
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A9
Name: UDP glucuronosyltransferase family 1 member A9
Acc ID: CHEBI:133920
Term: N-hydroxy-PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.
Chemical ID: MESH:C060533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A9increases glucuronidationEXP 6480464CTDUGT1A9 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:11375903 PMID:15310245
UGT1A9increases metabolic processingEXP 6480464CTDUGT1A9 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:15986396
UGT1A9multiple interactionsEXP 6480464CTDUGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]PMID:15986396
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