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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:133920
Term: N-hydroxy-PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.
Chemical ID: MESH:C060533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects metabolic processingISORGD:13500186480464CTDUGT1A1 promoter polymorphism affects the metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine

PMID:15986396
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine

PMID:11442279, PMID:15310245
increases metabolic processingISORGD:13500186480464CTDUGT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine

PMID:15986396
multiple interactionsISORGD:13500186480464CTDUGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine binds to Glucuronides], UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine binds to Glucuronides], UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine

PMID:15769885, PMID:15986396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.