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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rara
Name: retinoic acid receptor, alpha
Acc ID: CHEBI:133152
Term: 2-bromohexadecanoic acid
Definition: A bromo fatty acid that is hexadecanoic (palmitic) acid carrying a single bromo substituent at position 2.
Chemical ID: MESH:C022776
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raramultiple interactionsISORGD:7339996480464CTD2-bromopalmitate binds to and results in increased expression of RARA protein 2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein] 2-bromopalmitate inhibits the reaction [Tretinoin results in decreased expression of RARA protein] [2-bromopalmitate results in increased susceptibility to Tretinoin] which results in increased expression of RARA protein

PMID:30076181
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