Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:133021
Term: venetoclax
Definition: A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.
Chemical ID: MESH:C579720
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1increases expressionISORGD:7355126480464CTDvenetoclax results in increased expression of MCL1 protein

PMID:31837377
Mcl1multiple interactionsISORGD:7355126480464CTD[YM 155 co-treated with venetoclax] results in decreased expression of MCL1 protein

PMID:31837377
Go Back to source page   Continue to Ontology report