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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hk2
Name: hexokinase 2
Acc ID: CHEBI:132774
Term: roxadustat
Definition: An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Chemical ID: MESH:C584543
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hk2increases expressionISOHK2 (Homo sapiens)6480464CTDroxadustat results in increased expression of HK2 mRNAPMID:33596451
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