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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69095
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFB1
Name: transforming growth factor beta 1
Acc ID: CHEBI:131923
Term: salubrinal
Definition: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Chemical ID: MESH:C496827
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFB1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTDsalubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein]PMID:25398788
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