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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:131923
Term: salubrinal
Definition: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Chemical ID: MESH:C496827
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDsalubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein], salubrinal inhibits the reaction [Rotenone results in increased cleavage of CASP12 protein]

PMID:18226606, PMID:26446018
multiple interactionsISORGD:7314426480464CTDAcetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]], salubrinal inhibits the reaction [Rotenone results in increased expression of CASP12 mRNA], salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]

PMID:21616140, PMID:25428620
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.