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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68370
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
Acc ID: CHEBI:131851
Term: 680C91
Definition: A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.
Chemical ID: MESH:C093792
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tdo2decreases activityISORGD:685326480464CTDTDO inhibitor LM10 results in decreased activity of TDO2 protein

PMID:21726069
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