Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620058
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polk
Name: DNA polymerase kappa
Acc ID: CHEBI:131851
Term: 680C91
Definition: A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.
Chemical ID: MESH:C093792
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polkdecreases expressionISORGD:13439986480464CTDTDO inhibitor LM10 results in decreased expression of POLK protein

PMID:26651356
Go Back to source page   Continue to Ontology report